cellular proteases – Communicable Diseases Research

Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication

Article

Published on 2022-10-192022-11-15
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종, 치료제,

Protocol to isolate and assess spike protein cleavage in SARS-CoV-2 variants obtained from clinical COVID-19 samples

Article

Published on 2022-06-132022-10-05
Journal: STAR protocols
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,

Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteases

Article

Published on 2022-06-062022-11-01
Journal: Virus research
[Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] acute respiratory syndrome Amino acid amino acid substitution Analysis analyzed Antiviral approach binding cathepsin B cell receptor cellular cellular protease cellular proteases cleavage site cleaving coronavirus coronavirus pathogenesis develop domain functional furin furin cleavage site generate Health help Host host cell protease host protease host range incorporation indicated Infection inhibitor insight Interaction involved maturation MD simulation MD simulations molecular molecular docking multi Mutation plasmin polybasic primary determinant protease Protein proteolytic activation Receptor binding S protein S1 and S2 SARS-CoV-2 SARS-CoV-2 spike protein shown spike Spike protein Spread subunits the S protein tissue tropism
[DOI] 10.1016/j.virusres.2022.198845 PMC 바로가기 [Article Type] Article

In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties

특정 플라보노이드와 2019년 신종 코로나바이러스 수용체 결합 도메인의 상호작용 및 세포성 프로테아제 및 이들의 약동학적 특성에 대한 실리코 분석

Article

Published on 2022-04-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] COVID19(2023년), SARS, 치료제,

[키워드] 2019 2019 novel coronavirus 2019-nCoV acute respiratory syndrome coronavirus Analysis binding blood-brain barrier cathepsin B caused cellular protease cellular proteases Compound conducted coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death drug-likeness eukaryotic cells evaluated FIVE flavonoid flavonoids gallate glycoprotein hepatotoxicity hydrogen Hydrogen bond inhibit Interaction interactions microorganism MM/PBSA molecular molecular docking molecular dynamics molecular dynamics. Molecular mechanics nCoV P-glycoprotein pharmacokinetic Protein Proteins RBD Receptor binding domain respiratory SARS-CoV-2 Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein subgroup substrate supported surface area target proteins the receptor-binding domain TMPRSS2 Toxicity transmembrane serine protease transmembrane serine protease 2 Van
[DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article

Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study

돌연변이가 숙주 세포 수용체 ACE2와 인간 SARS-CoV-2의 수용체 결합 도메인의 구조, 기능 및 역학에 미치는 영향: 분자 역학 시뮬레이션 연구

Article

Published on 2021-11-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 변종,

[키워드] 6M0J ACE2 ACE2-RBD Affect Alanine alanine mutant alanine mutants Analysis angiotensin angiotensin-converting enzyme-II binding binding affinity cellular protease cellular proteases complex complexes conserved coronavirus Critical Directed mutagenesis disease severity drug Effect entry of SARS-CoV-2 enzyme exhibit FIVE flexible host cell host cell receptor human ACE2 human SARS-CoV-2 hydrogen Infection information inhibitor initiate Interface residues intermolecular hydrogen bond MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation molecular interaction motif Mutagenesis mutant Mutation priming Principal component provide RBD RBM recent Receptor binding Receptor binding domain receptor binding motif receptor binding motif. Receptor-binding domain Replication rate residue residues SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Spike protein supported the binding affinity the receptor-binding domain viral spike protein ward wild-type
[DOI] 10.1080/07391102.2020.1802348 PMC 바로가기 [Article Type] Article

Possible Therapeutic Use of Natural Compounds Against COVID-19

Article

Published on 2021-02-182022-10-29
Journal: Journal of cellular signaling
[Category] COVID-19,

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

SARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다

Research Article

Published on 2021-01-252022-08-13
Journal: PLoS Pathogens
[Category] COVID-19, Medicine and Health Sciences,

[키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article

Aprotinin Inhibits SARS-CoV-2 Replication

아프로티닌은 SARS-CoV-2 복제를 억제합니다

Article

Published on 2020-10-302022-09-11
Journal: Cells
[Category] MERS, SARS, 진단, 치료제,

[키워드] 2019-nCoV acute respiratory syndrome air–liquid interface Alpha Analysis Anti-SARS-CoV-2 Activity Antiviral approved Aprotinin Caco2 Calu Calu-3 Cell cell type cell types cellular proteases cleavage Concentration concentrations coronavirus coronavirus disease COVID-19 COVID-19 progression cultures disease downregulated downregulation Drug discovery epithelial epithelial cell host cell host cell protease host cell proteases indicated inhibited inhibitor isolates Local local control pandemic Prevent prevention of COVID-19 progression Protease inhibitor protease inhibitors Protein proteomics respiratory SARS-CoV-2 SARS-CoV-2 replication SERPINA1 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome virus systemic disease therapeutic virus virus entry virus replication
[DOI] 10.3390/cells9112377 PMC 바로가기 [Article Type] Article